Technical Bulletins

Efficacy of three disinfectant formulations and a hydrogen peroxide/silver fogging system on surfaces experimentally inoculated with methicillin-resistant Staphylococcus pseudintermedius

Soohoo J, Daniels JB, Brault SA, Rosychuk RAW, Schissler JR. | Veterinary Dermatology

Three disinfectants were tested against methicillin-resistant Staphylococcus pseudintermedius (MRSP), a leading cause of nosocomial infections in companion animals. AHP® achieved the greatest reduction in bacteria of the products tested. The HaloFogger fogging unit, using HaloMist disinfectant, was evaluated against the same bacteria, but produced significantly lower reductions.

Best Practices Document for the Management of Clostridium difficile "C. diff" in all Health Care Settings

Virox Technologies Inc. | Ontario Provincial Infectious Diseases Advisory Committee

This document was developed by the Provincial Infectious Diseases Advisory Committee (PIDAC). PIDAC is a multidisciplinary scientific advisory body who provide to the Chief Medical Officer of Health in Ontario evidence-based advice regarding multiple aspects of infectious disease identification, prevention and control. PIDAC’s work is guided by the best available evidence and updated as required. Best Practice documents and tools produced by PIDAC reflect consensus positions on what the committee deems prudent practice and are made available as a resource to the public health and health care providers.

Burden of Clostridium difficile infection on hospital readmissions and its potential impact under the Hospital Readmission Reduction Program

Virox Technologies Inc. | Chopra T. et al.

Although improved infection control efforts have been successful in decreasing the rates of many hospital-associated infections, Clostridium difficile infections (CDIs) still remain a problem. Accelerated Hydrogen Peroxide® (AHP®) is a patented disinfectant technology that is known for its effective cleaning properties as well as fast acting bactericidal and virucidal efficacy. AHP® surface disinfectants have been proven to reduce bacterial spore load on hard-non-porous surfaces .

Infection Prevention and Control Best Practices for Small Animal Veterinary Clinics

Virox Technologies Inc. | Canadian Committee on Antibiotic Resistance, 2008

This document was developed by the Canadian Committee on Antibiotic Resistance and is intended to guide clinical practice and provide assistance for decision-making on infection prevention and control issues. Furthermore, this document is designed to provide a complete and readily accessible summary of infection prevention and control best practices for small animal veterinary clinics, and is intended to be understandable to all members of the veterinary practice team.

Effects of contact time and concentration on bactericidal efficacy of 3 disinfectants on hard nonporous surfaces

Hong Y, Teska PJ, Oliver HF.

This study evaluated three disinfectants, including AHP®, against Staphylococcus aureus and Pseudomonas aeruginosa at a variety of off-label contact times and concentration. Invariably, reduced contact times and concentrations resulted in reduced efficacy in all disinfectants, highlighting the importance of adhering to label directions.

Effects of disinfection on the molecular detection of porcine epidemic diarrhea virus

Bowman A, Nolting J, Nelson S, Bliss N, Stull J, Wang Q, Premanandan C.

Routine detection of porcine epidemic diarrhea (PEDv) is currently limited to RT-PCR testing, as it is the only test method that can directly detect PEDv. Because RT-PCR only detects the viral RNA, a positive RT-PCR result only indicates the presence of PEDv viral RNA, but does not mean viable and infectious virus is present. Accelerated Hydrogen Peroxide®(AHP®) is a relatively new yet proven technology that is capable of disinfecting PEDv but may still leave inactivated RNA strands on surfaces, and therefore has a history of producing RT-PCR positive test results. In this study AHP was tested along with a number of other disinfectant actives as agents against PEDv using RT-PCR. Positive RT-PCR results were tested to show how AHP was able to fully inactivate any remaining RNA on the surface. Therefore, AHP can be used as an alternative disinfectant that is effective against PEDv without the negative toxicity, environmental, safety and compatibility profiles.

Evaluation of disinfectants and wiping substrates combinations to inactivate Staphylococcus aureus on Formica coupons

Brown, E., Dhanireddy, K., Waldron, C., Teska, P., Eifert, J. and Boyer, R.

Three disinfectants were each paired with three wiping substrates to compare their relative efficacies against S. aureus on Formica surfaces such as those common in hospitals. Sodium hypochlorite and accelerated hydrogen peroxide (AHP®)-based products applied with the cotton or microfiber cloths, respectively, demonstrated the greatest antimicrobial efficacy overall.

UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol

Alfa M.J., Dueck C., Olson N., DeGagne P., Papetti S., Wald A., Lo E. and Harding G.

Environmental survival of antibiotic resistant organisms has been suspected to play a role in nosocomial transmission of pathogens. When patients are diagnosed with infections, they are put on isolation precautions and for pathogens such as C. difficile, the housekeeping cleaning protocols are enhanced to reduce the environmental load and potential for cross contamination and as a result the risk of acquiring nosocomial infections. In this study an ultraviolet visible marker (UVM) was used to assess the cleaning compliance of housekeeping staff for toilets in a healthcare setting. The aim of this project was to determine if a UVM could be used to determine the compliance of housekeeping staff with the twice daily cleaning protocols for patients who have been placed on isolation precautions because of CDAD (C. difficile associated diarrhea).

Biofilms

Stewart P, Stoodley P, Gilbert P, McBain A, Bierman S, Dreeszen P, Thompson B, Budgell S, Ceri H.

Biofilms are nothing new to our world. They can be found in any environment that has a flow of water and a contact surface. Biofilms can be deleterious or beneficial depending on where they are found and which organisms they are comprised of. As a society, however, we most commonly associate the issue of biofilms with their related infections. Examples of these are otitis media and bacterial endocarditis, which are caused by bacteria entering a fluid filled part of the body. Accelerated Hydrogen Peroxide® (AHP®) is relatively new yet proven technology that has gained a reputation as being one of the most effective yet safe technologies on the market. In fact, two studies have been conducted using AHP highlighting its ability to kill and remove biofilms. This document will help you and decision makers to better understand what Biofilms are and the relevance of using a disinfectant capable of killing and removing them.

How Reliable are ATP Bioluminescence Meters in Assessing Decontamination of Environmental Surfaces in Healthcare Settings?

Navid Omidbakhsh, Faraz Ahmadpour, Nicole Kenny

This study evaluated the ability of four ATP bioluminescence meters to accurately determine the efficacy of disinfectants in healthcare settings. By comparing ATP bioluminescence meter results to actual cell culture tests, the researchers determined that these widely-used meters may not always provide accurate results, and that their activity may be affected by various disinfectant ingredients.