Technical Bulletins

Efficacy of three disinfectant formulations and a hydrogen peroxide/silver fogging system on surfaces experimentally inoculated with methicillin-resistant Staphylococcus pseudintermedius

Soohoo J, Daniels JB, Brault SA, Rosychuk RAW, Schissler JR. | Veterinary Dermatology

Three disinfectants were tested against methicillin-resistant Staphylococcus pseudintermedius (MRSP), a leading cause of nosocomial infections in companion animals. AHP® achieved the greatest reduction in bacteria of the products tested. The HaloFogger fogging unit, using HaloMist disinfectant, was evaluated against the same bacteria, but produced significantly lower reductions.

Evaluation of disinfectants and wiping substrates combinations to inactivate Staphylococcus aureus on Formica coupons

Brown, E., Dhanireddy, K., Waldron, C., Teska, P., Eifert, J. and Boyer, R.

Three disinfectants were each paired with three wiping substrates to compare their relative efficacies against S. aureus on Formica surfaces such as those common in hospitals. Sodium hypochlorite and accelerated hydrogen peroxide (AHP®)-based products applied with the cotton or microfiber cloths, respectively, demonstrated the greatest antimicrobial efficacy overall.

Best Practices Document for the Management of Clostridium difficile "C. diff" in all Health Care Settings

Virox Technologies Inc. | Ontario Provincial Infectious Diseases Advisory Committee

This document was developed by the Provincial Infectious Diseases Advisory Committee (PIDAC). PIDAC is a multidisciplinary scientific advisory body who provide to the Chief Medical Officer of Health in Ontario evidence-based advice regarding multiple aspects of infectious disease identification, prevention and control. PIDAC’s work is guided by the best available evidence and updated as required. Best Practice documents and tools produced by PIDAC reflect consensus positions on what the committee deems prudent practice and are made available as a resource to the public health and health care providers.

Burden of Clostridium difficile infection on hospital readmissions and its potential impact under the Hospital Readmission Reduction Program

Virox Technologies Inc. | Chopra T. et al.

Although improved infection control efforts have been successful in decreasing the rates of many hospital-associated infections, Clostridium difficile infections (CDIs) still remain a problem. Accelerated Hydrogen Peroxide® (AHP®) is a patented disinfectant technology that is known for its effective cleaning properties as well as fast acting bactericidal and virucidal efficacy. AHP® surface disinfectants have been proven to reduce bacterial spore load on hard-non-porous surfaces .

Infection Prevention and Control Best Practices for Small Animal Veterinary Clinics

Virox Technologies Inc. | Canadian Committee on Antibiotic Resistance, 2008

This document was developed by the Canadian Committee on Antibiotic Resistance and is intended to guide clinical practice and provide assistance for decision-making on infection prevention and control issues. Furthermore, this document is designed to provide a complete and readily accessible summary of infection prevention and control best practices for small animal veterinary clinics, and is intended to be understandable to all members of the veterinary practice team.

Effects of contact time and concentration on bactericidal efficacy of 3 disinfectants on hard nonporous surfaces

Hong Y, Teska PJ, Oliver HF.

This study evaluated three disinfectants, including AHP®, against Staphylococcus aureus and Pseudomonas aeruginosa at a variety of off-label contact times and concentration. Invariably, reduced contact times and concentrations resulted in reduced efficacy in all disinfectants, highlighting the importance of adhering to label directions.

Effects of disinfection on the molecular detection of porcine epidemic diarrhea virus

Bowman A, Nolting J, Nelson S, Bliss N, Stull J, Wang Q, Premanandan C.

Routine detection of porcine epidemic diarrhea (PEDv) is currently limited to RT-PCR testing, as it is the only test method that can directly detect PEDv. Because RT-PCR only detects the viral RNA, a positive RT-PCR result only indicates the presence of PEDv viral RNA, but does not mean viable and infectious virus is present. Accelerated Hydrogen Peroxide®(AHP®) is a relatively new yet proven technology that is capable of disinfecting PEDv but may still leave inactivated RNA strands on surfaces, and therefore has a history of producing RT-PCR positive test results. In this study AHP was tested along with a number of other disinfectant actives as agents against PEDv using RT-PCR. Positive RT-PCR results were tested to show how AHP was able to fully inactivate any remaining RNA on the surface. Therefore, AHP can be used as an alternative disinfectant that is effective against PEDv without the negative toxicity, environmental, safety and compatibility profiles.

UV-visible marker confirms that environmental persistence of Clostridium difficile spores in toilets of patients with C. difficile-associated diarrhea is associated with lack of compliance with cleaning protocol

Alfa M.J., Dueck C., Olson N., DeGagne P., Papetti S., Wald A., Lo E. and Harding G.

Environmental survival of antibiotic resistant organisms has been suspected to play a role in nosocomial transmission of pathogens. When patients are diagnosed with infections, they are put on isolation precautions and for pathogens such as C. difficile, the housekeeping cleaning protocols are enhanced to reduce the environmental load and potential for cross contamination and as a result the risk of acquiring nosocomial infections. In this study an ultraviolet visible marker (UVM) was used to assess the cleaning compliance of housekeeping staff for toilets in a healthcare setting. The aim of this project was to determine if a UVM could be used to determine the compliance of housekeeping staff with the twice daily cleaning protocols for patients who have been placed on isolation precautions because of CDAD (C. difficile associated diarrhea).

2009 Guide to Hygiene and Sanitation in Aviation

Virox Technologies Inc. | World Health Organization

This document was developed by a panel of experts from around the globe in partnership with the World Health Organization (WHO) for aviation transport providers to address the various sanitary requirements within the aircraft and airports. Particular attention is paid to the cleaning and disinfection requirements for effective infection prevention and the criteria with which cleaning and disinfectant products should be chosen. Accelerated Hydrogen Peroxide® (AHP®) performs exceptionally well within each category. AHP strikes a balance between rapid, broad spectrum germicidal efficacy and maintenance of an exceptional personal health and environmental profile. In fact, on page 39 of the document reference is made to hydrogen peroxide-based disinfectants containing surfactants and chelating agents (AHP) which are reporting excellent results in other industries.

Cleaning assessment of disinfectant cleaning wipes on an external surface of a medical device contaminated with artificial blood or Streptococcus pneumoniae

Gold K., and Hitchins V. | Office of Science and Engineering Laboratories, Center for Devices and Radiological Health

Improperly cleaned, disinfected, or sterilized reusable medical devices are a critical cause of health care-associated infections. Device-associated HAIs (DA-HAIs) are among the main causes of patient morbidity and mortality within hospital intensive care units. It has also been suggested that DA-HAIs account for 60-80% of all bloodstream, urinary tract, and pneumonia-related HAIs, signifying a need for new infection control measures to reduce the involvement of medical devices in such infections. One of the critical issues that need to be considered when designing new infection control measures is the influence of physical design and materials used in fabrication on the reprocessing of reusable medical devices. More effective studies are required to address the improvement of cleaning and disinfection instructions, as well as selection of cleaning and disinfecting agents, for surfaces of reusable devices and equipment.